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Journal article

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Abstract:

An immune response is essential for protection against infection, but, in many individuals, aberrant responses against self tissues cause autoimmune diseases such as rheumatoid arthritis (RA). How to diminish the autoimmune response while not augmenting infectious risk is a challenge. Modern targeted therapies such as anti-TNF or anti-CD20 antibodies ameliorate disease, but at the cost of some increase in infectious risk. Approaches that might specifically reduce autoimmunity and tissue damag...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1321071111

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
6
Pages:
2289-2294
Publication date:
2014-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:762cfd41-dd80-4d3a-8d59-2340e1cb009d
Source identifiers:
448000
Local pid:
pubs:448000

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