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Journal article

CD45 regulates apoptosis in peripheral T lymphocytes.

Abstract:

Programmed cell death (apoptosis) is a key mechanism for regulating lymphocyte numbers. Murine lymph node lymphocytes cultured in vitro without added stimuli show significant levels of apoptosis over 24 h, detectable by staining with Annexin V. CD4 and CD8 T lymphocytes from transgenic (Tg) mice expressing single CD45RABC or CD45RO isoforms show increased apoptosis and the extent of apoptosis is inversely correlated with the level of CD45 expression. CD45 Tg cells exhibit phosphatidyl serine ...

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Publisher copy:
10.1093/intimm/dxl032

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
International immunology
Volume:
18
Issue:
6
Pages:
959-966
Publication date:
2006-06-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:7622497b-6847-4924-84d2-8afcc37c1af8
Source identifiers:
33446
Local pid:
pubs:33446

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