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Analysis with the exome array identifies multiple new independent variants in lipid loci.

Abstract:

It has been hypothesised that low frequency (1-5% MAF) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27,312 individuals with a comprehensive set of low frequency coding variants (ExomeChip), combined with conditional analysis in the known lipid loci. No new locus reached genome-wide signifi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/hmg/ddw227

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Department:
Oxford, MSD, RDM, OCDEM
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Department:
Green Templeton College
Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
25
Issue:
28
Pages:
4094-4106
Publication date:
2016-07-05
Acceptance date:
2016-07-08
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:634557
URN:
uri:76162574-99c8-4ca8-a877-0342c93ccda2
UUID:
76162574-99c8-4ca8-a877-0342c93ccda2
Local pid:
pubs:634557
Language:
English
Keywords:

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