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Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse.

Abstract:

Between December 1983 and November 1985 we treated 39 patients with chronic myeloid leukaemia by chemoradiotherapy and transplantation from HLA-identical sibling donors using bone marrow that had been depleted of T cells ex vivo with the rat monoclonal antibody Campath-1. Twenty-eight of the patients were in the chronic phase (good-risk group) and 11 patients were in more advanced phases of the disease (accelerated phase or blastic transformation; poor-risk group). Of the patients of good ris...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Bone marrow transplantation
Volume:
1
Issue:
1
Pages:
53-66
Publication date:
1986-05-05
EISSN:
1476-5365
ISSN:
0268-3369
URN:
uuid:761495c9-c3d4-4fa2-ab18-17e0d5ddb0b1
Source identifiers:
4101
Local pid:
pubs:4101

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