Journal article
Binuclear lanthanide complexes as magnetic resonance and optical imaging probes for redox sensing
- Abstract:
- We report a family of lanthanide(III) complexes that act as redox probes via both magnetic resonance (MR) and luminescence outputs. The ligands are functionalized with nitro, azobenzene and azide groups which are reduced to a common aniline product, and each responds to both chemical and biocatalytic reductive conditions at different cathodic onset potentials. By judicious choice of complexed Ln(III), the probes can be optimized either for use in MR imaging (Ln = Gd), or as highly efficient turn-on luminescence probes (Ln = Tb). The Tb(III) analogues are essentially nonemissive, until reductive generation of the aniline affords a complex which when excited by visible light (488 nm) emits green light with a quantum yield of 45% and millisecond long luminescent lifetimes (ms). The tunable redox response and imaging modalities of these versatile complexes have the potential to open up new approaches to redox sensing, such as the imaging of hypoxic environments in biology.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1002/chem.202404748
Authors
+ Engineering and Physical Sciences Research Council
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- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- EP/S023828/1
- EP/S019901/1
- Programme:
- OxICFM
+ Cancer Research UK
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- Funder identifier:
- https://ror.org/054225q67
- Grant:
- C6078/A2873
+ European Research Council
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- Funder identifier:
- https://ror.org/0472cxd90
- Grant:
- ERC CoG-819580
+ Swiss National Science Foundation
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- Funder identifier:
- https://ror.org/00yjd3n13
- Grant:
- P500PN_214322
- Publisher:
- Wiley
- Journal:
- Chemistry - A European Journal More from this journal
- Volume:
- 31
- Issue:
- 30
- Article number:
- e202404748
- Publication date:
- 2025-05-03
- Acceptance date:
- 2025-04-14
- DOI:
- EISSN:
-
1521-3765
- ISSN:
-
0947-6539
- Language:
-
English
- Keywords:
- Pubs id:
-
2118137
- Local pid:
-
pubs:2118137
- Deposit date:
-
2025-04-14
Terms of use
- Copyright holder:
- Simms et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Chemistry – A European Journal published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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