Journal article
Childhood leukaemia: long-term excess mortality and the proportion 'cured'
- Abstract:
- Survival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general population. Average time to cure is defined as the time since diagnosis at which the excess mortality rate has declined to or below a predetermined small value. Data on children diagnosed with leukaemia during 1971-2000 in Great Britain were used to estimate trends in survival, the proportion cured and the average time to cure. Five-year survival for all types of leukaemia combined rose from 33 to 79% by 2000, time to cure increased from 12 years (95% confidence interval (CI): 11-14) to 19 years (9% CI: 14-26) for lymphoid leukaemia (average annual increase of 0.3 years; P<0.001), but remained at about 5 years for acute nonlymphoblastic leukaemia. The proportion of children cured of leukaemia has risen dramatically, but the period of excess mortality associated with lymphoid leukaemia has also increased, possibly because of late relapse, secondary malignancy and toxicity from treatment.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 122.8KB, Terms of use)
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- Publisher copy:
- 10.1038/sj.bjc.6604466
- Publisher:
- Nature Publishing Group
- Journal:
- British Journal of Cancer More from this journal
- Volume:
- 99
- Issue:
- 1
- Pages:
- 219-223
- Publication date:
- 2008-07-01
- Edition:
- Publisher's version
- DOI:
- EISSN:
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1532-1827
- ISSN:
-
0007-0920
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
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uuid:760d38a8-a6a7-44b2-9313-460c924e82b6
- Local pid:
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ora:4861
- Deposit date:
-
2011-01-27
Terms of use
- Copyright holder:
- A Shah et al
- Copyright date:
- 2008
- Notes:
- Citation: Shah, A. et al. (2008). ' Childhood leukaemia: long-term excess mortality and the proportion 'cured'', British Journal of Cancer 99(1), 219-223. [Available at http://www.nature.com/bjc/archive/index.html]. Copyright 2008 Shah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial-Share-Alike 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited and the work is not used for commercial purposes. If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.
- Licence:
- Other
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