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Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria

Abstract:
Neisseria meningitidis and Neisseria gonorrhoeae are globally important pathogens, which in part owe their success to their ability to successfully evade human immune responses over long periods. The phase-variable opacity-associated (Opa) adhesin proteins are a major surface component of these organisms, and are responsible for bacterial adherence and entry into host cells and interactions with the immune system. Most immune interactions are mediated via binding to members ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
University of Toronto
Department:
Department of Molecular Genetics
Role:
Author

Contributors

Department of Health More from this funder
More from this funder
Funding agency for:
Pollard, A
More from this funder
Funding agency for:
Sadarangani, M
Publisher:
Blackwell Publishing Ltd. Publisher's website
Journal:
FEMS Microbiology Reviews Journal website
Volume:
35
Issue:
3
Pages:
498-514
Publication date:
2011-05-01
DOI:
EISSN:
1574-6976
Language:
English
Keywords:
Subjects:
UUID:
uuid:760451c0-b959-45b8-b8d1-fa4ab1c76d20
Local pid:
ora:5452
Deposit date:
2011-06-14

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