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A general copper-mediated nucleophilic 18F fluorination of arenes.

Abstract:

Molecules labeled with fluorine-18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [(18)F]F(-). In the ideal case, the (18)F fluorination of these substrates would be performed through reaction of [(18)F]KF with shelf-stable readily available precursors using a broadly applicable method suitable for automation. Herein, we describe the realization of these requirements wit...

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Publication status:
Published

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Publisher copy:
10.1002/anie.201404436

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Journal:
Angewandte Chemie (International ed. in English)
Volume:
53
Issue:
30
Pages:
7751-7755
Publication date:
2014-07-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
469509
Language:
English
Keywords:
Pubs id:
pubs:469509
UUID:
uuid:76028d73-e33f-4fef-9cb4-62f3ca0043d3
Local pid:
pubs:469509
Deposit date:
2014-08-14

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