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Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction.

Abstract:

The aging process in the hippocampus is associated with aberrant epigenetic marks, such as DNA methylation and histone tail alterations. Recent evidence suggests that caloric restriction (CR) can potentially delay the aging process, while upregulation of antioxidants may also have a beneficial effect in this respect. We have recently observed that CR attenuates age-related changes in the levels of the epigenetic molecules DNA methyltransferase 3a, 5-methylcytidine (5- mC) and 5-hydroxymethylc...

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Publisher copy:
10.2174/1567205011310080009

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
van den Hove, DL More by this author
Draanen, M More by this author
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Journal:
Current Alzheimer research
Volume:
10
Issue:
8
Pages:
868-876
Publication date:
2013-10-05
DOI:
EISSN:
1875-5828
ISSN:
1567-2050
URN:
uuid:75fdc851-be89-44ba-99a8-7622b4c5787f
Source identifiers:
456141
Local pid:
pubs:456141

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