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Thesis

Regulating stem cell fate within microenvironmental niches

Abstract:

Improving the repopulation potential of human umbilical cord blood (UCB) haemopoietic stem cells (HSCs) remains a paramount goal in HSC transplantation (HSCT) therapy. This implies enhancing the homing and engraftment potential of UCB-CD34+CD133+ cells to the bone marrow (BM). Although an array of molecules continues to be identified as ‘key’ homing molecules, the molecular mechanisms controlling HSC homing are still not fully understood. The regulatory implications of hypoxia in the BM, w...

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:75f9498c-30f0-4983-84b2-dd58f2ccf52b
Local pid:
ora:9197

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