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GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1.

Abstract:

The DNA-binding hemopoietic zinc finger transcription factor GATA1 promotes terminal megakaryocyte differentiation and restrains abnormal immature megakaryocyte expansion. How GATA1 coordinates these fundamental processes is unclear. Previous studies of synthetic and naturally occurring mutant GATA1 molecules demonstrate that DNA-binding and interaction with the essential GATA1 cofactor FOG-1 (via the N-terminal finger) are required for gene expression in terminally differentiating megakaryoc...

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Publication status:
Published

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Journal:
Molecular and cellular biology
Volume:
25
Issue:
19
Pages:
8592-8606
Publication date:
2005-10-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:75f90f00-698b-4e4b-a8db-dfe92a484411
Source identifiers:
33230
Local pid:
pubs:33230

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