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Journal article

Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models

Abstract:

Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. The incidence of infection failures and high intra-group variation means that large group sizes are required for drug testing. Further, a lack of accurate, quantitative adult biomarkers results in protracted timeframes or multiple groups for endpoint analyses. Here we evaluate i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1038/s41598-018-24294-2

Authors


Marriott, AE More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
ORCID:
0000-0003-1948-6779
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 5910
Publication date:
2018-04-12
Acceptance date:
2018-03-21
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:842350
URN:
uri:75ef255a-ed3d-439d-9a7c-43d16931f828
UUID:
uuid:75ef255a-ed3d-439d-9a7c-43d16931f828
Local pid:
pubs:842350

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