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High frequency stimulation of the subthalamic nucleus modulates neuronal activity in the lateral habenula nucleus

Abstract:

High frequency stimulation (HFS) of the subthalamic nucleus (STN) is often used to treat movement disability in advanced Parkinson's disease, but some patients experience debilitating psychiatric effects including depression. Interestingly, HFS of the STN modulates 5-HT neurons in the dorsal raphe nucleus (DRN) which are linked to depression, but the neural substrate of this effect is unknown. Here we tested the effect of STN stimulation on neuronal activity in the lateral habenula nucleus (L...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1111/ejn.13397

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Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Department:
Oxford, MSD, Pharmacology
Role:
Author
Hersenstichting Nederland More from this funder
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
European Journal of Neuroscience Journal website
Volume:
44
Issue:
9
Pages:
2698–2707
Publication date:
2016-09-13
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Pubs id:
pubs:646062
URN:
uri:75eb1c41-49e9-4d51-8d00-2452696e1041
UUID:
uuid:75eb1c41-49e9-4d51-8d00-2452696e1041
Local pid:
pubs:646062
Paper number:
9

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