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The functions and relationships of Ty-VLP proteins in yeast reflect those of mammalian retroviral proteins.

Abstract:

We have identified the major structural core proteins of Ty virus-like particles (Ty-VLPs) and shown that they are generated by proteolytic cleavage of the primary translation product of TYA, p1. This precursor protein is therefore functionally similar to the gag precursor of retroviruses. Cleavage is mediated by a Ty-encoded protease located at the 5' region of TYB and is accompanied by a change in particle morphology. p1 contains sufficient information for the assembly of a pre-Ty-VLP compl...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Cell
Volume:
49
Issue:
1
Pages:
111-119
Publication date:
1987-04-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:75e36bad-94b2-4bb6-ba18-fa6334f78349
Source identifiers:
8691
Local pid:
pubs:8691

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