Journal article icon

Journal article

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Abstract:

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associate...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pgen.1002025

Authors


Expand authors...
Wellcome Trust More from this funder
Arthritis Research Campaign More from this funder
European Community's Seventh Framework Programme More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
4
Pages:
e1002025
Publication date:
2011-04-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:75cc8eb6-3abe-48f4-99ea-aa193873e989
Source identifiers:
146593
Local pid:
pubs:146593

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP