- Abstract:
-
Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associate...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 791.9KB)
-
- Publisher copy:
- 10.1371/journal.pgen.1002025
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 7
- Issue:
- 4
- Pages:
- e1002025
- Publication date:
- 2011-04-05
- DOI:
- EISSN:
-
1553-7404
- ISSN:
-
1553-7390
- URN:
-
uuid:75cc8eb6-3abe-48f4-99ea-aa193873e989
- Source identifiers:
-
146593
- Local pid:
- pubs:146593
- Language:
- English
- Keywords:
- Copyright date:
- 2011
- Notes:
- This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Journal article
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
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Wellcome Trust
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Arthritis Research Campaign
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European Community's Seventh Framework Programme
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ENGAGE
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