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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Abstract:

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002025

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Funding agency for:
Perry, J
Grant:
092447/Z/10/Z
Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
European Community's Seventh Framework Programme More from this funder
Arthritis Research Campaign More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
4
Article number:
e1002025
Publication date:
2011-04-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
146593

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