Journal article
Vaccinia virus immunomodulator A46: A lipid and protein-binding scaffold for sequestering host TIR-domain proteins.
- Abstract:
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Vaccinia virus interferes with early events of the activation pathway of the transcriptional factor NF-kB by binding to numerous host TIR-domain containing adaptor proteins. We have previously determined the X-ray structure of the A46 C-terminal domain; however, the structure and function of the A46 N-terminal domain and its relationship to the C-terminal domain have remained unclear. Here, we biophysically characterize residues 1-83 of the N-terminal domain of A46 and present the X-ray struc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.2MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.ppat.1006079
Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Pathogens More from this journal
- Volume:
- 12
- Issue:
- 12
- Pages:
- e1006079
- Publication date:
- 2016-12-01
- Acceptance date:
- 2016-11-19
- DOI:
- EISSN:
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1553-7374
- ISSN:
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1553-7366
- Pmid:
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27973613
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:746614
- UUID:
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uuid:75c94628-5d3f-40eb-9f59-c69f788a1e31
- Local pid:
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pubs:746614
- Source identifiers:
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746614
- Deposit date:
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2017-12-20
Terms of use
- Copyright holder:
- Fedosyuk et al
- Copyright date:
- 2016
- Notes:
- © 2016 Fedosyuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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