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Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Abstract:
), lower fasting glucose, and greater insulin sensitivity. Predicted loss-of-function variants are associated with lower odds of T2D among 32,015 cases and 84,006 controls (odds ratio 0.71, 95% confidence interval 0.49-0.99, p = 0.041). Functional studies in Angptl4-deficient mice confirm improved insulin sensitivity and glucose homeostasis. In conclusion, genetic inactivation of ANGPTL4 is associated with improved glucose homeostasis and reduced risk of T2D.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-04611-z

Authors


Gusarova, V More by this author
O'Dushlaine, C More by this author
Teslovich, TM More by this author
Benotti, PN More by this author
More by this author
ORCID:
0000-0002-0754-3820
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
2252
Publication date:
2018-06-13
Acceptance date:
2018-05-10
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:857279
URN:
uri:75c51119-529b-424c-a0ff-bafa4a3f9207
UUID:
uuid:75c51119-529b-424c-a0ff-bafa4a3f9207
Local pid:
pubs:857279
Language:
English
Keywords:

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