Journal article icon

Journal article

Evidence for expression and function of phosphodiesterase type 5 (PDE-V) in rat resistance arteries.

Abstract:

Evidence is provided for expression and a functional role for phosphodiesterase type V (PDE-V) in the rat isolated small mesenteric artery. The reverse transcription polymerase chain reaction (RT--PCR) demonstrated mRNA for PDE-V, while Western blotting and immunocytochemical studies showed corresponding protein expression. Smooth muscle relaxation to the nitric oxide donor, diethylamine NONOate (DEA NONOate; 1 nM - 10 microM; pEC(50)=6.7+/-0.3) was potentiated significantly by the specific i...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.bjp.0703831

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
British journal of pharmacology
Volume:
132
Issue:
1
Pages:
13-17
Publication date:
2001-01-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:75bc79cf-375c-4a29-a847-d1c5b83fcfaf
Source identifiers:
106300
Local pid:
pubs:106300

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP