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Durable interactions of T cells with T cell receptor stimuli in the absence of a stable immunological synapse

Abstract:

T cells engage in two modes of interaction with antigen-presenting surfaces: stable synapses and motile kinapses. Although it is surmised that durable interactions of T cells with antigen-presenting cells involve synapses, in situ 3D imaging cannot resolve the mode of interaction. We have established in vitro 2D platforms and quantitative metrics to determine cell-intrinsic modes of interaction when T cells are faced with spatially continuous or restricted stimulation. All major resting human...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.12.052

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS; KIR
Judokusumo, E More by this author
Abu Shah, E More by this author
Wiggins, CH More by this author
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Funding agency for:
Dustin, M
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Funding agency for:
Dustin, M
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
22
Issue:
2
Pages:
340-349
Publication date:
2018-01-09
Acceptance date:
2017-12-14
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:817463
URN:
uri:75b9a8e0-5f5a-41f9-80ba-6106fdde01c3
UUID:
uuid:75b9a8e0-5f5a-41f9-80ba-6106fdde01c3
Local pid:
pubs:817463

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