Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.

Journal article

Abstract:: Observations on patients with Cushing's syndrome highlight the important role of glucocorticoids in regulating body fat distribution, specifically their link with central obesity. Circulating cortisol concentrations, however, are normal in the majority of patients with simple obesity. 'Pre-receptor' activation of cortisol from inactive cortisone by an enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), expressed within adipose tissue itself, is emerging as a pivotal mechanism in regula...
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Author

Institution:

University of Oxford

Division:

MSD

Department:

RDM

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Author

Journal:: Trends in endocrinology and metabolism: TEM More from this journal
Volume:: 13
Issue:: 3
Pages:: 94-96
Publication date:: 2002-04-01
DOI:: 10.1016/s1043-2760(02)00566-0
EISSN:: 1879-3061
ISSN:: 1043-2760

Language:: English
Keywords:: 11-beta-Hydroxysteroid Dehydrogenases

Adipose Tissue

Hydroxysteroid Dehydrogenases

Stromal Cells

Humans

Adipocytes

Cushing Syndrome

Hydrocortisone

Obesity
Pubs id:: pubs:482070
UUID:: uuid:75b89a47-c1ed-4ab0-b54b-7602526850a7
Local pid:: pubs:482070
Source identifiers:: 482070
Deposit date:: 2014-08-29

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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