Plasmid-borne 16S rRNA methylase ArmA in aminoglycoside-resistant Klebsiella pneumoniae in Poland.

Journal article

We characterized 17 clinical isolates of Klebsiella pneumoniae producing 16S rRNA methylase ArmA. The isolates originated in Poland from 2002 to May 2010 and encompassed four XbaI-PFGE clusters. All the isolates were resistant to amikacin, gentamicin and kanamycin (MIC range: 256-1024 mg l(-1)) and carried the armA gene on a large plasmid of approximately 90 or 130 kb in 15 and 2 isolates, respectively. The armA gene was found in a ~10 kb ClaI restriction fragment of the large plasmid and was...

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Authors: Zacharczuk, K; Piekarska, K; Szych, J; Jagielski, M; Hidalgo, L

• Journal: Journal of medical microbiology
• Volume: 60
• Issue: Pt 9
• Pages: 1306-1311
• Publication date: 2011-09-01
• DOI: 10.1099/jmm.0.024026-0
• EISSN: 1473-5644
• ISSN: 0022-2615
• Language: English
• Keywords: RNA, Bacterial; DNA, Bacterial; Gene Transfer, Horizontal; Plasmids; Klebsiella pneumoniae; Methyltransferases; Klebsiella Infections; Drug Resistance, Bacterial; Aminoglycosides; Microbial Sensitivity Tests; beta-Lactamases; Poland; Methylation; Humans; Anti-Bacterial Agents; DNA Transposable Elements; RNA, Ribosomal, 16S