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Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration

Abstract:

BACKGROUND: Declining anti-malarial efficacy of artemisinin-based combination therapy, and reduced Plasmodium falciparum susceptibility to individual anti-malarials are being documented across an expanding area of Southeast Asia (SEA). Genotypic markers complement phenotypic studies in assessing the efficacy of individual anti-malarials. METHODS: The markers pfmdr1 and pfcrt were genotyped in parasite samples obtained in 2011-2014 at 14 TRAC (Tracking Resistance to Artemisinin Collaboration) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-016-1598-6

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Oxford college:
St John's College
Role:
Author
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Royal Golden Jubilee Ph.D. Programme More from this funder
Thailand Research Fund More from this funder
Mahidol University More from this funder
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Grant:
090532/Z/09/Z
098051
090770/Z/09/Z
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Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
15
Issue:
1
Article number:
541
Publication date:
2016-11-08
Acceptance date:
2016-10-31
DOI:
ISSN:
1475-2875
Source identifiers:
660325
Language:
English
Keywords:
Pubs id:
pubs:660325
UUID:
uuid:759bd6f7-b94a-4a72-8c13-c0ae48c47db5
Local pid:
pubs:660325
Deposit date:
2016-12-07

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