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A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.

Abstract:

We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda. The trial was open label and 800 patients were randomly assigned to AQ+SP (n=400) or CD+A (n=400). Patients were hospitalised for 3 days and then followed-up weekly until Day 28 after treatment. Clinical and parasitological out...

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
102
Issue:
5
Pages:
412-420
Publication date:
2008-05-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
Source identifiers:
290336
Language:
English
Keywords:
Pubs id:
pubs:290336
UUID:
uuid:7592c6bc-b79f-4be3-a076-55d718ac576d
Local pid:
pubs:290336
Deposit date:
2014-05-13

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