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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Abstract:

Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor-prognosis leukemias. Here, we find that at a subset of gene targets, MLL-AF4 binding spreads into the gene body and is associated with the spreading of Menin binding, increased transcription, increased H3K79 methylation (H3K79me2/3), a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.12.054

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Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
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Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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National Institute for Health Research More from this funder
UCSF Academic Senate More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
18
Issue:
2
Pages:
482-495
Publication date:
2017-01-10
Acceptance date:
2016-12-16
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:670826
URN:
uri:757c5208-a4dd-4c3e-9f0a-7480ca10d07c
UUID:
uuid:757c5208-a4dd-4c3e-9f0a-7480ca10d07c
Local pid:
pubs:670826

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