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Journal article

Detection of transient protein folding populations by mass spectrometry.

Abstract:

Hydrogen-deuterium exchange measurements are becoming increasingly important in studies of the dynamics of protein molecules and, particularly, of their folding behavior. Electrospray ionization mass spectrometry (ESI-MS) has been used to obtain the distribution of masses within a population of protein molecules that had undergone hydrogen exchange in solution. This information is complementary to that from nuclear magnetic resonance spectroscopy (NMR) experiments, which measure the average o...

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Publication status:
Published

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Publisher copy:
10.1126/science.8235611

Authors


Miranker, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Radford, SE More by this author
Dobson, CM More by this author
Journal:
Science (New York, N.Y.)
Volume:
262
Issue:
5135
Pages:
896-900
Publication date:
1993-11-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:757b16ac-c778-431d-a0f7-20c8c6a98124
Source identifiers:
59346
Local pid:
pubs:59346

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