- Abstract:
-
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng.2390
-
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- Journal:
- Nature genetics
- Volume:
- 44
- Issue:
- 10
- Pages:
- 1142-1146
- Publication date:
- 2012-10-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:756f0362-beac-4c5c-bf43-1a0740ba194a
- Source identifiers:
-
349953
- Local pid:
- pubs:349953
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
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