Journal article icon

Journal article

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Abstract:

BACKGROUND: The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of anticancer agents. To date our knowledge of catalytic domain structures of the PIM kinase family is limited to PIM1 which has been extensively studied and which shares about 50% sequence identity with PIM2. PRINCIPAL FINDINGS: Here we deter...

Expand abstract
Publication status:
Published

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0007112

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Bregman, H More by this author
Expand authors...
Canadian Institutes for Health Research More from this funder
Canadian Foundation for Innovation More from this funder
Ontario Genomics Institute More from this funder
GlaxoSmithKline More from this funder
Karolinska Institutet More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
10
Pages:
Article: e7112
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:75641f80-06c0-4e70-925f-48b0614b6a27
Source identifiers:
34939
Local pid:
pubs:34939

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP