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Journal article

Memory B cell response to a PCV-13 booster in 3.5year old children primed with either PCV-7 or PCV-13.

Abstract:

Pneumococcal protein-polysaccharide conjugate vaccines provide direct protection against Streptococcus pneumoniae through the induction of persistent anti-polysaccharide antibodies, and by priming for a rapid secondary antibody response. Memory B cells (BMEM) generated during an initial immune response are responsible for both the more rapid and quantitatively greater secondary antibody response and are also thought to contribute to the ongoing production of plasma cells providing long-term a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.vaccine.2017.03.079

Authors


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Department:
Oxford, MSD, Paediatrics
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Department:
Oxford, MSD, Paediatrics
Morales-Aza, B More by this author
More by this author
Department:
Oxford, MSD, Paediatrics
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Department:
Oxford, MSD, Primary Care Health Sciences
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University of Oxford More from this funder
Pfizer Vaccine Research More from this funder
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
35
Issue:
20
Pages:
2701-2708
Publication date:
2017-04-05
Acceptance date:
2017-03-29
DOI:
ISSN:
1873-2518
Pubs id:
pubs:689218
URN:
uri:7554eb7e-1e41-4cbe-86f8-2c8ffd391657
UUID:
uuid:7554eb7e-1e41-4cbe-86f8-2c8ffd391657
Local pid:
pubs:689218

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