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Bioinformatic and mutational analysis of ophiovirus movement proteins, belonging to the 30K superfamily

Abstract:

Ophioviridae is a family of segmented, negative-sense, single-stranded RNA plant viruses. We showed that their cell-to-cell movement protein (MP) is an isolated member of the 30K MP superfamily with a unique structural organization. All 30K MPs share a core domain that contains a nearly-invariant signature aspartate. We examined its role in the MP of Citrus psorosis virus (CPsV) and Mirafiori lettuce big-vein virus (MiLBVV). Alanine substitution of this aspartate prevented plasmodesmata accum...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.virol.2016.08.027

Authors


Borniego, MB More by this author
More by this author
Department:
Oxford, MSD, Structural Biology
García, ML More by this author
More from this funder
Funding agency for:
Karlin, D
Publisher:
Elsevier Publisher's website
Journal:
Virology Journal website
Volume:
498
Pages:
174-180
Publication date:
2016-09-04
Acceptance date:
2016-08-27
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
Pubs id:
pubs:646459
URN:
uri:7553fa82-eb3a-4985-94ef-3917c5b56aa5
UUID:
uuid:7553fa82-eb3a-4985-94ef-3917c5b56aa5
Local pid:
pubs:646459

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