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Metabolic changes during carcinogenesis: potential impact on invasiveness.

Abstract:

Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell-microenvironmental interactions that mediate somatic evolution of cancer cells. This allows investigation of the hypothesis that regions of premalignant lesions develop a substrate-limited environment as proliferation carries cells away from blood vessels which remain separated by the intact basement membrane. We f...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2006.09.010

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
Journal of theoretical biology
Volume:
244
Issue:
4
Pages:
703-713
Publication date:
2007-02-01
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Source identifiers:
8814

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