- Abstract:
-
Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell-microenvironmental interactions that mediate somatic evolution of cancer cells. This allows investigation of the hypothesis that regions of premalignant lesions develop a substrate-limited environment as proliferation carries cells away from blood vessels which remain separated by the intact basement membrane. We f...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jtbi.2006.09.010
-
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- Journal:
- Journal of theoretical biology
- Volume:
- 244
- Issue:
- 4
- Pages:
- 703-713
- Publication date:
- 2007-02-05
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- URN:
-
uuid:753b6226-c68a-48bf-8392-4f43c8456343
- Source identifiers:
-
8814
- Local pid:
- pubs:8814
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Metabolic changes during carcinogenesis: potential impact on invasiveness.
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