Journal article icon

Journal article

CRAC channels drive digital activation and provide analog control and synergy to Ca(2+)-dependent gene regulation.

Abstract:

Ca(2+)-dependent gene expression is critical for cell growth, proliferation, plasticity, and adaptation [1-3]. Because a common mechanism in vertebrates linking cytoplasmic Ca(2+) signals with activation of protein synthesis involves the nuclear factor of activated T cells (NFAT) family of transcription factors [4, 5], we have quantified protein expression in single cells following physiological Ca(2+) signals by using NFAT-driven expression of a genetically encoded fluorescent protein. We fi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.cub.2011.12.025

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Current biology : CB
Volume:
22
Issue:
3
Pages:
242-247
Publication date:
2012-02-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:753b29b2-a7ab-4ac7-b5cf-163be05f2bb5
Source identifiers:
237243
Local pid:
pubs:237243

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP