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Palladium-catalyzed cross-coupling reactions of pyridylboronic acids with heteroaryl halides bearing a primary amine group: synthesis of highly substituted bipyridines and pyrazinopyridines.

Abstract:

A range of halogenated aromatics and heteroaromatics bearing a primary amine group are shown to be suitable substrates for Suzuki cross-coupling reactions with arylboronic acids and pyridylboronic acids under standard conditions, without the need for protection/deprotection steps. New amino-substituted arylpyridines, bipyridines, and pyrazinopyridines have thereby been obtained. Conditions for the efficient syntheses of 2-methoxy-5-pyridylboronic acid 1 and 2-methoxy-3-pyridylboronic acid 2 i...

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Publisher copy:
10.1021/jo0402226

Authors


Thompson, AE More by this author
Batsanov, AS More by this author
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Journal:
The Journal of organic chemistry
Volume:
70
Issue:
1
Pages:
388-390
Publication date:
2005-01-05
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
URN:
uuid:75224935-e220-4f5c-9f06-9d2e53bf47cf
Source identifiers:
117269
Local pid:
pubs:117269
Language:
English

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