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MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.

Abstract:

microRNAs (miRNAs) represent a novel class of genome-encoded eukaryotic regulatory RNAs that silence gene expression posttranscriptionally. Although the proteins mediating miRNA biogenesis and function have been identified, the precise mechanism by which miRNAs regulate the expression of target mRNAs remains unclear. We summarize recent work from our laboratory demonstrating that miRNAs silence gene expression by at least two independent mechanisms: by repressing translation and/or by promoti...

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Publisher copy:
10.1101/sqb.2006.71.013

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Journal:
Cold Spring Harbor symposia on quantitative biology
Volume:
71
Issue:
0
Pages:
523-530
Publication date:
2006-01-01
DOI:
EISSN:
1943-4456
ISSN:
0091-7451
URN:
uuid:75184452-7827-481f-994e-47447cf5890e
Source identifiers:
353649
Local pid:
pubs:353649

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