Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients.

Journal article

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic aci...

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Authors: Nassimizadeh, M; Ashrafian, H; Drury, N; Howell, N; Digby, J

• Publication status: Published
• Journal: Diabetes and vascular disease research : official journal of the International Society of Diabetes and Vascular Disease
• Volume: 7
• Issue: 3
• Pages: 213-215
• Publication date: 2010-07-01
• DOI: 10.1177/1479164110376207
• EISSN: 1752-8984
• ISSN: 1479-1641
• Language: English
• Keywords: Humans; Microscopy, Electron; Diabetic Angiopathies; Surface Properties; Diabetes Mellitus, Type 2; Ferritins; N-Acetylneuraminic Acid; Case-Control Studies; Glycocalyx; Staining and Labeling; Mammary Arteries; Endothelium, Vascular