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An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.

Abstract:

Signaling pathways controlled by reversible protein phosphorylation (catalyzed by kinases and phosphatases) in the malaria parasite Plasmodium are of great interest, for both increased understanding of parasite biology and identification of novel drug targets. Here, we report a functional analysis in Plasmodium of an ancient bacterial Shewanella-like protein phosphatase (SHLP1) found only in bacteria, fungi, protists, and plants. SHLP1 is abundant in asexual blood stages and expressed at all ...

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Journal:
Cell reports
Volume:
3
Issue:
3
Pages:
622-629
Publication date:
2013-03-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:75053431-fce3-4b6c-b940-cc578469e239
Source identifiers:
396254
Local pid:
pubs:396254

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