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Interferon-gamma induces HLA-DR expression by thyroid epithelium.

Abstract:

We recently showed that human thyroid epithelial cells, which are normally negative for HLA-DR molecules, express HLA-DR in thyroid autoimmunity. Furthermore, induction of HLA-DR on normal thyroid cells can be achieved by culture with plant lectins. We have now found that recombinant human interferon-gamma (IFN-gamma) induces expression of HLA-DR molecules on cultured human thyroid cells, whereas Namalva IFN-alpha, recombinant IFN-beta or recombinant interleukin-2 (IL-2) do not. All three IFN...

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Publication status:
Published

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Authors


Pujol-Borrell, R More by this author
Hammond, LJ More by this author
Bottazzo, GF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Clinical and experimental immunology
Volume:
61
Issue:
2
Pages:
265-273
Publication date:
1985-08-05
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:74f2bcec-bab3-408e-9c01-6a636e3cd364
Source identifiers:
481693
Local pid:
pubs:481693

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