Journal article icon

Journal article

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation.

Abstract:

Progeny of mice treated with the mutagen N-ethyl-N-nitrosourea (ENU) revealed a mouse, designated Longpockets (Lpk), with short humeri, abnormal vertebrae, and disorganized growth plates, features consistent with spondyloepiphyseal dysplasia congenita (SEDC). The Lpk phenotype was inherited as an autosomal dominant trait. Lpk/+ mice were viable and fertile and Lpk/Lpk mice died perinatally. Lpk was mapped to chromosome 15 and mutational analysis of likely candidates from the interval revealed...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/jbmr.547

Authors


Testori, S More by this author
Expand authors...
Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
27
Issue:
2
Pages:
413-428
Publication date:
2012-02-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:74f0600b-203f-45eb-bf2a-c08b181b4046
Source identifiers:
383956
Local pid:
pubs:383956

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP