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Journal article

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.

Abstract:

The heterodimeric transcription factor HIF (hypoxia-inducible factor) is central to the regulation of gene expression by oxygen. Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF. In the presence of oxygen, they hydroxylate specific proline residues in HIF-alpha, allowing recognition by pVHL (von Hippel-Lindau protein) and subsequent ubiquitylation and proteasomal destruction. The precise roles and regulation of ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20051996

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
The Biochemical journal
Volume:
397
Issue:
1
Pages:
179-186
Publication date:
2006-07-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:74ecac96-92d9-40b7-a575-a8129a83b164
Source identifiers:
25413
Local pid:
pubs:25413

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