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Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations.

Abstract:

Autoantibodies to Shaker-type (Kv1) K+ channels are now known to be associated with three syndromes. Peripheral nerve hyperexcitability is the chief manifestation of acquired neuromyotonia; the combination of neuromyotonia with autonomic and CNS involvement is called Morvan's syndrome (MoS); and CNS manifestations without peripheral involvement is called limbic encephalitis (LE). To determine the cellular basis of these clinical manifestations, we immunostained mouse neural tissues with sera ...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awl084

Authors


Kleopa, KA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Scherer, SS More by this author
Journal:
Brain : a journal of neurology
Volume:
129
Issue:
Pt 6
Pages:
1570-1584
Publication date:
2006-06-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:74e3a9ec-deec-414c-93d6-a4a12dcb820d
Source identifiers:
346146
Local pid:
pubs:346146

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