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Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement.

Abstract:

BACKGROUND: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered parasites and can be used to estimate the total parasite burden. We investigated the prognostic significance of plasma PfHRP2 and used it to estimate the malaria-attributable fraction in African children diagnosed with severe mala...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001297

Authors


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Institution:
University of Oxford
Mwanga-Amumpaire, J More by this author
von Seidlein, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
9
Issue:
8
Pages:
Article: e1001297
Publication date:
2012
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:74e3a173-4ec6-4748-8246-4671e5b279a4
Source identifiers:
349772
Local pid:
pubs:349772

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