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Journal article

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia.

Abstract:

A chronic stress paradigm comprising exposure to predation, tail suspension and restraint induces a depressive syndrome in C57BL/6J mice that occurs in some, but not all, animals. Here, we sought to extend our behavioural studies to investigate how susceptibility (sucrose preference<65%) or resilience (sucrose preference>65%) to stress-induced anhedonia affects the 5HT system and the expression of inflammation-related genes. All chronically stressed animals, displayed increased level of...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbi.2012.12.017

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Brain, behavior, and immunity
Volume:
29
Pages:
136-146
Publication date:
2013-03-01
DOI:
EISSN:
1090-2139
ISSN:
0889-1591
Source identifiers:
374290

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