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Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice.

Abstract:

Induction of mixed hematopoietic chimerism results in donor-specific immunological tolerance by apoptosis-mediated deletion of donor-reactive lymphocytes. A broad clinical application of this approach is currently hampered by limited predictability and toxicity of the available conditioning protocols. We developed a new therapeutic approach to induce mixed chimerism and tolerance by a direct pharmacological modulation of the intrinsic apoptosis pathway in peripheral T cells. The proapoptotic ...

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Publication status:
Published

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Authors


Cippà, PE More by this author
Gabriel, SS More by this author
Bardwell, PD More by this author
Bushell, A More by this author
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Journal:
Blood
Volume:
122
Issue:
9
Pages:
1669-1677
Publication date:
2013-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:74de1fa8-2c92-4853-9c56-d9bceab1a62b
Source identifiers:
414761
Local pid:
pubs:414761

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