Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice.

Journal article

Induction of mixed hematopoietic chimerism results in donor-specific immunological tolerance by apoptosis-mediated deletion of donor-reactive lymphocytes. A broad clinical application of this approach is currently hampered by limited predictability and toxicity of the available conditioning protocols. We developed a new therapeutic approach to induce mixed chimerism and tolerance by a direct pharmacological modulation of the intrinsic apoptosis pathway in peripheral T cells. The proapoptotic ...

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Authors: Cippà, P; Gabriel, S; Chen, J; Bardwell, P; Bushell, A

• Publication status: Published
• Journal: Blood
• Volume: 122
• Issue: 9
• Pages: 1669-1677
• Publication date: 2013-08-01
• DOI: 10.1182/blood-2012-09-453944
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Hematopoiesis; Apoptosis; Nitrophenols; Transplantation Tolerance; Mice, Inbred C57BL; Sulfonamides; Graft Survival; Mice, Inbred CBA; Mice, Inbred BALB C; Biphenyl Compounds; Mice, Knockout; Mice; Immunosuppression; Piperazines; Animals; Transplantation Conditioning; Transplantation Chimera; Cells, Cultured; Molecular Targeted Therapy; Up-Regulation; Proto-Oncogene Proteins c-bcl-2