Journal article icon

Journal article

Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.

Abstract:

Nitric oxide (NO) donors increase heart rate (HR) through a guanylyl cyclase-dependent stimulation of the pacemaker current I(f), without affecting basal I(Ca-L). The activity of I(f)is known to be enhanced by cyclic nucleotides and by an increase in cytosolic Ca(2+). We examined the role of cGMP-dependent signaling pathways and intracellular Ca(2+)stores in mediating the positive chronotropic effect of NO donors. In isolated guinea pig atria, the increase in HR in response to 1-100 micromol/...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/jmcc.2000.1216

Authors


Musialek, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Journal of molecular and cellular cardiology
Volume:
32
Issue:
10
Pages:
1831-1840
Publication date:
2000-10-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:74d612b8-02f1-4535-a97a-0e974478268f
Source identifiers:
104881
Local pid:
pubs:104881

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP