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The role of NLRs in induction and resolution of intestinal inflammation

Abstract:

Innate immune activation is thought to play a central role in IBD pathogenesis because genetic polymorphisms in NOD2 and NLRP3, cytosolic innate immune receptors belonging to the NLR family, have been associated with IBD susceptibility. However, the mechanisms through which NLR mutations predispose to IBD remain unclear. The aim of this project was to dissect the functional roles of different NLRs in intestinal inflammation. Using the well-established DSS-induced colitis model as well as e...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathology
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:74c0e3a2-82ae-4311-8abe-21926835bc17
Local pid:
ora:7507

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