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U1 snRNA associates with TFIIH and regulates transcriptional initiation.

Abstract:

Diverse classes of noncoding RNA, including small nuclear RNAs (snRNAs), play fundamental regulatory roles at many stages of gene expression. For example, recent studies have implicated 7SK RNA and components of the splicing apparatus in the regulation of transcriptional elongation. Here we present the first evidence of the involvement of an snRNA in the regulation of transcriptional initiation. We demonstrate that TFIIH, a general transcription initiation factor, specifically associates with...

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Publication status:
Published

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Publisher copy:
10.1038/nsb862

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Nature structural biology
Volume:
9
Issue:
11
Pages:
800-805
Publication date:
2002-11-05
DOI:
ISSN:
1072-8368
URN:
uuid:74bfefb3-53df-4659-8d85-acdc7aa786ed
Source identifiers:
5080
Local pid:
pubs:5080

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