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Journal article

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

Abstract:

We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner, with increased brittleness. Osteoblast activity is reduced as reflected in a reduced bone formation rate and failure to differentiate to a mature mineralizing stage. Bmp2 in osteoblasts also indirectly controls angiogenesis in the periosteum and bone marrow. VegfA production is re...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.118596

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Journal:
Journal of cell science
Volume:
126
Issue:
Pt 18
Pages:
4085-4098
Publication date:
2013-09-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:749fcd55-e07e-46b8-9bad-c8260cfbafd7
Source identifiers:
432730
Local pid:
pubs:432730

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