- Abstract:
-
We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner, with increased brittleness. Osteoblast activity is reduced as reflected in a reduced bone formation rate and failure to differentiate to a mature mineralizing stage. Bmp2 in osteoblasts also indirectly controls angiogenesis in the periosteum and bone marrow. VegfA production is re...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/jcs.118596
-
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- Journal:
- Journal of cell science
- Volume:
- 126
- Issue:
- Pt 18
- Pages:
- 4085-4098
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- URN:
-
uuid:749fcd55-e07e-46b8-9bad-c8260cfbafd7
- Source identifiers:
-
432730
- Local pid:
- pubs:432730
- Copyright date:
- 2013
Journal article
Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.
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