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Molecular dynamics simulations of a bacterial autotransporter: NalP from Neisseria meningitidis.

Abstract:

NalP is an autotransporter secretory protein found in the outer membrane of Neisseria meningitidis. The crystal structure of the NalP translocator domain revealed a transmembrane beta-barrel containing a central alpha-helix. The role of this alpha-helix, and of the conformational dynamics of the beta-barrel pore have been studied via atomistic molecular dynamics simulations. Three simulations, each of 10 ns duration, of NalP embedded within a solvated DMPC bilayer were performed. The helix wa...

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Publication status:
Published

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Publisher copy:
10.1080/09687860600849531

Authors


Journal:
Molecular membrane biology
Volume:
23
Issue:
6
Pages:
499-508
Publication date:
2006-01-01
DOI:
EISSN:
1464-5203
ISSN:
0968-7688
URN:
uuid:7489dea6-0ac4-4b2d-ba19-82e85d5ad331
Source identifiers:
100748
Local pid:
pubs:100748

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