Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells.

Journal article

Inoculation of macaques with live attenuated SIV strains has been shown to protect against subsequent challenge with wild-type SIV. The protective mechanism(s) remain obscure. To study the effect in more detail, we have investigated the role of virus-specific CTL responses in macaques infected with an attenuated SIV strain (pC8), which has a four-amino acid deletion in the nef gene, as compared with the wild-type SIVmac32H clone (pJ5). Cynomolgus macaques infected with pC8 were protected agai...

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Authors: Xu, X; Screaton, G; Gotch, F; Dong, T; Tan, R

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 186
• Issue: 1
• Pages: 7-16
• Publication date: 1997-07-01
• DOI: 10.1084/jem.186.1.7
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Animals; Acquired Immunodeficiency Syndrome; Flow Cytometry; Fas Ligand Protein; Simian Acquired Immunodeficiency Syndrome; CD8-Positive T-Lymphocytes; Membrane Glycoproteins; CD4-Positive T-Lymphocytes; Humans; Immunity, Cellular; Simian immunodeficiency virus; Jurkat Cells