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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

Abstract:

T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched in lysobisphosphatidic acid, a lipid involved in sorting ubiquitinated membrane proteins for degradation. Calcium signaling via TCR was blocked within 2 min by anti-MHCp treatmen...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunity
Volume:
25
Issue:
1
Pages:
117-127
Publication date:
2006-07-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:747e71f9-23d8-4155-a0eb-83c25ad27f9f
Source identifiers:
482609
Local pid:
pubs:482609

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