- Abstract:
-
T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched in lysobisphosphatidic acid, a lipid involved in sorting ubiquitinated membrane proteins for degradation. Calcium signaling via TCR was blocked within 2 min by anti-MHCp treatmen...
Expand abstract - Publisher copy:
- 10.1016/j.immuni.2006.04.010
-
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- Journal:
- Immunity
- Volume:
- 25
- Issue:
- 1
- Pages:
- 117-127
- Publication date:
- 2006-07-05
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- URN:
-
uuid:747e71f9-23d8-4155-a0eb-83c25ad27f9f
- Source identifiers:
-
482609
- Local pid:
- pubs:482609
- Copyright date:
- 2006
Journal article
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.
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