Journal article
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.
- Abstract:
-
T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched in lysobisphosphatidic acid, a lipid involved in sorting ubiquitinated membrane proteins for degradation. Calcium signaling via TCR was blocked within 2 min by anti-MHCp treatmen...
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- Publisher copy:
- 10.1016/j.immuni.2006.04.010
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Authors
Bibliographic Details
- Journal:
- Immunity
- Volume:
- 25
- Issue:
- 1
- Pages:
- 117-127
- Publication date:
- 2006-07-01
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- Source identifiers:
-
482609
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:482609
- UUID:
-
uuid:747e71f9-23d8-4155-a0eb-83c25ad27f9f
- Local pid:
- pubs:482609
- Deposit date:
- 2014-09-14
Terms of use
- Copyright date:
- 2006
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