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Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever.

Abstract:

Naloxone, an opioid antagonist, and meptazinol, an opioid antagonist with agonist properties, were tested in a double-blind placebo-controlled trial in 24 Ethiopian patients with louse-borne relapsing fever. The potentially fatal Jarisch-Herxheimer reaction (J-HR), which invariably follows tetracycline treatment of the disease, was unaffected by naloxone, 30-40 mg intravenously, but was diminished by meptazinol, 300-500 mg intravenously. Compared with naloxone and placebo, meptazinol reduced ...

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Publication status:
Published

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Authors


Habte-Michael, A More by this author
Warrell, DA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Wright, DJ More by this author
Journal:
Lancet
Volume:
1
Issue:
8329
Pages:
835-839
Publication date:
1983-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:7463eb5d-c0ce-44c0-adb2-093670030ec0
Source identifiers:
42135
Local pid:
pubs:42135

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